Featuring Epicutis
Medical-Grade Skincare in Dover, NH
Biotech-backed, barrier-first skincare that calms inflammation, supports your microbiome, and keeps every formula minimal. It’s the same line Harley uses in her treatment room.
Professional-only | EWG VERIFIED® | Available at HSS
Why Epicutis
Skincare born from biotechnology
Epicutis grew out of more than 20 years of research at Signum Biosciences. Instead of piling on actives, each formula is built around a short list of ingredients chosen to calm inflammation, restore the skin barrier, and keep your microbiome in balance.
At the core are patented ingredients you won’t find anywhere else, like TSC, a lipid-like ingredient that calms inflammatory signals in the skin,1,2 and HYVIA®, a chia seed extract shown to boost hydration and support barrier function.3 Epicutis is also the only fully EWG VERIFIED® skincare line sold exclusively through licensed professionals.
The HSS Difference
Low and slow, barrier first
Corrective results don’t come from stripping your skin. They come from calming it down, rebuilding the barrier, and then correcting gently and consistently.
Epicutis fits the way Harley works. You’ll feel it in your facial, and she’ll help you build a simple at-home routine so your results keep improving between visits.
Is It Right For You?
Made for skin that needs a reset
Epicutis is gentle enough for reactive skin and effective enough for corrective goals. It’s a great fit if you’re dealing with:
Redness + Sensitivity
Calms visibly irritated, reactive skin without a long list of harsh actives.
Dehydration + Barrier Damage
Lipid-rich hydration helps repair a stressed, compromised barrier.
Hyperpigmentation + Uneven Tone
Targeted brightening for dark spots and dullness, without irritation.
Breakout-Prone Skin
Microbiome-balancing formulas support clearer, calmer skin.
Post-Treatment Recovery
Soothes and comforts skin after peels, extractions, and other treatments.
Everyday Maintenance
A simple, minimal routine to keep healthy skin healthy.
Step 1 · Cleanse
Cleanse + Prep
Start with a cleanse that removes the day without stripping your barrier.
Oil Cleanser
A silky cleansing oil that melts away makeup, sunscreen, and buildup, then rinses clean so skin feels soft, never tight or greasy. Made with HYVIA®, a chia seed extract that boosted skin hydration in a small clinical study.3
Hydrobiome Mist
A prebiotic + postbiotic mist that hydrates, soothes, and supports a balanced microbiome. It features AGSE, an enriched grape seed extract that outperformed vitamins C and E as an antioxidant and calmed UV-triggered inflammation in lab studies.4
Step 2 · Treat
Targeted Serums + Treatments
Concentrated, minimal formulas that target the root of your skin concerns.
Lipid Serum
The signature serum. A lightweight, eight-ingredient formula built on TSC, a lipid-like ingredient that calmed UV- and irritant-triggered inflammatory signals in skin cells, rivaling a potent prescription steroid in lab tests.1,2 Ideal for stressed, sensitive, or post-treatment skin.
Hydrobiome Serum
A fast-absorbing serum that helps balance the microbiome and calm visible irritation with TCP. In an 8-week clinical study of blemish-prone skin, 1% TCP (studied as SIG1459) improved acne scores by about 77%, outperforming 3% benzoyl peroxide.7
Arctigenin Brightening Treatment
Powered by ABSO, a burdock seed extract with about 5x more arctigenin. It reduced melanin by 52% in a lab skin model, and in an 8-week clinical study, skin tone evenness improved 18%.5 Also contains HYVIA® for hydration.3
Step 3 · Hydrate + Protect
Moisturize + Defend
Lock in hydration and protect your progress every single day.
Hyvia® Crème
A rich, dewy treatment cream with ceramides and shea butter that supports the barrier and helps protect against environmental stress. Its namesake HYVIA® increased skin hydration by about 58% vs. a placebo cream at 24 hours in a small clinical study.3 Safe to use around the eyes.
Lipid Shield SPF 30
Daily SPF 30 to finish your morning routine and protect your results, formulated with TSC, the same calming lipid ingredient found in the Lipid Serum.1,2
Recovery Masks
Masks for Calm, Recovered Skin
Bio-cellulose masks with a concentrated dose of the Lipid Serum formula. Ten to fifteen minutes to calm, soothe, and rehydrate.
Lipid Recovery Mask
A soothing bio-cellulose face mask infused with TSC1,2 for redness, dehydration, and stressed skin. Perfect before an event or after a treatment.
Lipid Recovery Mask for Eyes
Targeted care for the delicate eye area with TSC1,2 plus QFC, which increased the skin’s own water channels (aquaporin-3) in lab studies.6 Hydrates and refreshes tired-looking eyes.
Lipid Recovery Mask for Neck + Décolleté
Extends that calm, hydrated finish to the neck and chest.
Body
Barrier Care Below the Neck
Your body deserves barrier-first skincare too.
Lipid Body Treatment
A lightweight body gel with HYVIA®3 that delivers long-lasting hydration and helps improve the look of dry, loose, or crepey skin on the arms, legs, and torso.
Sets
Simplify Your Routine
Not sure where to start? Sets bundle Epicutis essentials into one easy routine.
Luxury Skincare Set
The core of the Epicutis routine: Lipid Serum (with TSC1,2) + Hyvia® Crème (with HYVIA®3), together in one set.
Cleansing Essentials Set
Our Oil Cleanser paired with the Enzyme Exfoliating Powder. Gentle enzymes lift away dull, dead skin, so you get a fresh, smooth finish without harsh scrubbing. Formulated with HYVIA®.3
The Science
Research behind the ingredients
Epicutis ingredients are backed by published research. These are the studies referenced on this page:
- Fernández JR, et al. SIG1273: a new cosmetic functional ingredient to reduce blemishes and Propionibacterium acnes in acne prone skin. J Cosmet Dermatol. 2012;11:272–278. (Cited by Epicutis for TSC.)
- Fernandez JR, et al. Anti-inflammatory and anti-bacterial properties of tetramethylhexadecenyl succinyl cysteine (TSC): a skin-protecting cosmetic functional ingredient. Int J Cosmet Sci. 2015;37:129–133.
- Huber KL, et al. HYVIA™: a novel, topical chia seed extract that improves skin hydration. J Cosmet Dermatol. 2020.
- Huber KL, et al. AGSE: a novel grape seed extract enriched for PP2A activating flavonoids that combats oxidative stress and promotes skin health. Molecules. 2021;26:6351.
- Ishii T, et al. Arctigenin-enriched burdock seed oil (ABSO): a new skin brightening botanical extract. Cosmetics. 2023;10:10.
- Fernández JR, et al. N-Acetylglutaminoyl-S-farnesyl-L-cysteine (SIG-1191): an anti-inflammatory molecule that increases the expression of the aquaglyceroporin, aquaporin-3, in human keratinocytes. Arch Dermatol Res. 2017;309:103–110. (Cited by Epicutis for QFC.)
- Fernández JR, et al. SIG1459: a novel phytyl-cysteine derived TLR2 modulator with in vitro and clinical anti-acne activity. Exp Dermatol. 2018;27:993–999. (Cited by Epicutis for TCP.)
Studies were conducted by or in partnership with Signum Biosciences, the developer of these ingredients. Many are lab (in vitro) or small clinical studies, and individual results vary. This information describes cosmetic ingredients and is not intended to diagnose, treat, or cure any condition.
Get Started
Find your Epicutis routine
New to Epicutis?
Book a complimentary skin consultation. Harley will assess your skin and current routine, then recommend the Epicutis products that make sense for you, and nothing you don’t need.
Already a Client?
Pick up your Epicutis products at your next appointment, or shop online. Ask Harley anytime if you’re not sure what to add next.
Book Online
Book your skin consultation
Book a complimentary skin consultation below. We’ll talk through your skin goals and build an Epicutis routine that fits your skin and your lifestyle.
Questions
Frequently Asked Questions
“Medical-grade” isn’t an official FDA category. It usually refers to professional-only skincare that’s sold through licensed skin professionals, not in drugstores or big-box retailers. Epicutis is exclusive to the professional channel, so you’ll get it with guidance from someone who knows your skin.
Yes. Epicutis is built around calming inflammation and supporting the skin barrier, with short, minimal ingredient lists. That makes it a great fit for sensitive, reactive, or easily irritated skin.
Yes. Harley uses Epicutis in the treatment room, so you’ll get to experience how your skin responds before you take anything home.
Epicutis is available at the studio, and select products are available in the online shop. Not sure what to get? Book a complimentary consultation or ask at your next appointment.
Many people notice calmer, more comfortable, hydrated skin soon after starting. Changes in tone, texture, and pigmentation take longer and build with consistent daily use. True to the HSS approach, it’s low and slow.
Often, yes. Bring your current routine to your consultation and Harley will help you decide what to keep, what to swap, and how to layer everything.
Healthy skin starts with a healthy barrier
Pair your Epicutis routine with a customized facial at Harley Shayna Skin in Dover, NH.
